Schizophrenia pathophysiology: are we any closer to a complete model?

Schizophrenia pathophysiology: are we any closer to a complete model?

Schizophrenia, a severe brain disorder that involves hallucinations, disordered thinking and deficiencies in cognition, has been studied for decades in order to determine the early events that lead to this neurological disorder. In this review, we interpret the developmental and genetic models that have been proposed and treatment options associated with these models. Schizophrenia was initiall...

Are we any closer to combating Ebola infections?

In March, 2009, a scientist working in a highcontainment laboratory in Germany pricked herself with a needle that had just been used to infect a mouse with the Ebola virus. Although rare, similar laboratory accidents with Ebola virus have been reported in the UK (1976), USA (2004), and Russia (2004), of which the one in Russia was fatal. Additionally, there have been at least three exposures to...

Why are we not getting any closer to preventing suicide?

Optimal Usage of Colistin: Are We Any Closer?

Despite being the mainstay of treatment for carbapenem-resistant gram-negative bacilli for more than a decade, optimal strategies for dosing and administration of colistin remain unclear. Colistin dosing regimens vary considerably throughout the world. In some instances, the total daily dose delivered varies 2-fold depending on geography. Compounding the issue is the fact that the majority of d...

Off-pump vs. on-pump CABG: are we any closer to a resolution?

Afilalo and colleagues have presented an updated meta-analysis and meta-regression of randomized trials of off-pump vs. on-pump coronary artery bypass grafting (CABG) surgery. Their two major findings are that while there was a reduction in mortality, myocardial infarction, and stroke in the off-pump group, this only reached significance for the latter, and that the effect of off-pump CABG was ...